Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability

Self-healing hydrogel products have attracted a great deal of interest in wound healing due to their ability repair own structural damage. Herein, an all-natural self-healing based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) is developed. MA used modify CS obtain water-soluble biomaterial-based CSMA with photo crosslinking effects. BC modified through simple oxidation method gain the polymer chain. The success modification confirmed via FTIR. Hydrogels are formed within 11 min establishment Schiff base between amino aldehyde DABC. A dynamically reversible bond endows good properties macroscopic microscopic observations. We observe uniform porous structure using SEM images, DABC nanofibers found be well distributed hydrogel. compressive strength more than 20 kPa swelling rate sees over 10-fold increase. In addition, CSMA/DABC has cytocompatibility, cell viability exceeding 90%. These results indicate that self-healable demonstrates strong application potential tissue repair.